In an experiment, neutrophils collected from peripheral blood are analyzed for a “burst” of oxygen consumption. This respiratory burst is an essential step for which of the following events in an acute inflammatory response?
Increased production of leukocytes in bone marrow
Attachment to endothelial cells
Opsonization of bacteria
Phagocytosis of bacteria
Generation of microbicidal activity
A 5-year-old child has a history of recurrent bacterial infections, including pneumonia and otitis media. Analysis of leukocytes collected from the peripheral blood shows a deficiency in myeloperoxidase. Which of the following is the most likely cause of this child's increased susceptibility to infections?
Defective neutrophil degranulation
Defective production of prostaglandins
Failure to produce hydroxy-halide radicals (HOCl-)