База тестів крок-1 з патофізіології (пмк-1)

For the past 2 days, a 41-year-old man has had a severe headache, and he now has a temperature of 39.2°C. A lumbar puncture is performed, and the cerebrospinal fluid obtained has a WBC count of 9×10⁹/L with 94% neutrophils and 6% lymphocytes. Which of the following substances is the most likely mediator for the fever observed in this patient?

1. 
   Bradykinin
   
2. 
   Leukotriene B4
   
3. 
   Histamine
   
4. 
   Myeloperoxidase
   
5. 
   Interleukin-1
   

A 6-year-old child has a history of recurrent infections with pyogenic bacteria, including Staphylococcus aureus and Streptococcus pneumonia. The infections are accompanied by a neutrophilic leukocytosis. Microscopic examination of a biopsy specimen obtained from an area of soft tissue necrosis shows microbial organisms, but very few neutrophils. An analysis of neutrophil function shows a defect in rolling. This child's increased susceptibility to infection is most likely caused by a defect in which of the following molecules?

1. 
   Selectins
   
2. 
   Integrins
   
3. 
   Leukotriene B4
   
4. 
   Complement C3b
   
5. 
   NADPH oxidase