База тестів крок-1 з патофізіології (пмк-1)


Typical metabolic disorders



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Typical metabolic disorders.

Diabetes

  1. Prolonged fasting causes hypoglycemia which is amplified by alcohol consumption, as the following process is inhibited:

    1. Gluconeogenesis

    2. Glycolysis

    3. Glycogenolysis

    4. Lipolysis

    5. Proteolysis



  1. A 39-year-old female patient with a history of diabetes was hospitalized in a precomatose state for diabetic ketoacidosis. This condition had been caused by an increase in the following metabolite level:

    1. Acetoacetate

    2. Citrate

    3. Alpha-ketoglutarate

    4. Malonate

    5. Aspartate



  1. Examination of a 56-year-old female patient with a history of type 1 diabetes revealed a disorder of protein metabolism that is manifested by aminoacidemia in the laboratory blood test values, and clinically by the delayed wound healing and decreased synthesis of antibodies. Which of the following mechanisms causes the development of aminoacidemia?

    1. Increased proteolysis

    2. Albuminosis

    3. Decrease in the concentration of amino acids in blood

    4. Increase in the oncotic pressure in the blood plasma

    5. Increase in low-density lipoprotein level




  1. A child has a history of hepatomegaly, hypoglycemia, seizures, especially on an empty stomach and in stressful situations. The child is diagnosed with Gierke disease. This disease is caused by the genetic defect of the following enzyme:

    1. Glucose-6-phosphatase

    2. Amyloid-1,6-glycosidase

    3. Phosphoglucomutase

    4. Glycogen phosphorylase

    5. Glucokinase




  1. Characteristic sign of glycogenosis is muscle pain during physical work.

Blood examination reveals usually hypoglycemia. This pathology is caused by congenital deficiency of the following enzyme:

    1. Glycogen phosphorylase

    2. Glucose 6-phosphate dehydrogenase

    3. Alpha amylase

    4. Gamma amylase

    5. Lysosomal glycosidase



  1. Before the cells can utilize the glucose, it is first transported from the extracellular space through the plasmatic membrane inside them. This process is stimulated by the following hormone:

    1. Insulin

    2. Glucagon

    3. Thyroxin

    4. Aldosterone

    5. Adrenalin



  1. A female patient complains of vision impairment. On examination she was found to have obesity, fasting hyperglycemia. What complication of diabetes can cause vision impairment?

    1. Microangiopathy

    2. Macroangiopathy

    3. Atherosclerosis

    4. Neuropathy

    5. Glomerulopathy




  1. A patient with insulin-dependent diabetes mellitus has been administered insulin. After a certain period of time the patient developed fatigue, irritability, excessive sweating. What is the main mechanism of such presentations developing?



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