База тестів крок-1 з патофізіології (пмк-1)



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Test 127

In an evaluation of an 8-year-old boy who has had recurrent infections since the first year of life, findings include enlargement of the liver and spleen, lymph node inflammation, and a superficial dermatitis resembling eczema. Microscopic examination of a series of peripheral blood smears taken during the course of a staphylococcal infection indicates that the bactericidal capacity of the boy’s neutrophils is impaired or absent. What is the most likely cause of this child’s illness?



  1. Defect in the enzyme NADPH oxidase

  2. Abnormal fusion of phagosomes to primary lysosomes

  3. Defect in the IL-2 receptor

  4. Developmental defect at the pre-B stage

  5. Defect in T cells maturation




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